Larsulin SC Injection 100IU/ml-Pen Cartridge 3ml

Uses of Larsulin SC Injection 100IU/ml

• Type 1 Diabetes Mellitus
• Type II Diabetes Mellitus

How does Larsulin SC Injection 100IU/ml work?

Larsulin SC Injection 100IU/ml is a long-acting modified form of insulin that works similarly to human insulin. It improves blood sugar control by enhancing glucose uptake from the blood into body tissues and also by preventing the production of glucose in the liver.

Side Effects of Larsulin SC Injection 100IU/ml

• Low blood sugar or hypoglycemia
• Cold sweat
• Confusion
• Cool pale skin
• Anxious feeling
• Unusual tiredness or weakness
• Nervousness
• Difficulty in concentration
• Drowsiness
• Excessive hunger
• Temporary vision changes
• Increased pulse or heartbeat (palpitation)

Quick Suggestions:

• Exercise can lower your body's insulin requirements during and after physical activity.
• Physical activity might also enhance insulin's effects, especially in the injected area (avoid injecting in an active area like the leg before exercise).
• Consult your doctor to adjust your insulin plan for exercise.
• Choose low-calorie, cooked foods over sugary options.
• If traveling across multiple time zones, consult your doctor about insulin schedule adjustments.
• Rotate injection sites within the chosen area to prevent skin issues like lipodystrophy or lumps.
• Avoid using the same spot for multiple injections or damaged skin.
• Discuss any skin issues with your doctor, such as tenderness, bruising, scarring, or other abnormalities.

Indication

Insulin Glargine is used in the treatment of Diabetes Mellitus (Type 1 & Type 2).

Pharmacology

Insulin Glargine is a sterile solution intended for subcutaneous injection. It is a synthetic form of insulin produced using recombinant DNA technology, designed to mimic human insulin. This long-acting insulin analog provides steady blood sugar control for up to 24 hours. Its primary function is to regulate glucose metabolism by enhancing glucose uptake in skeletal muscle and fat tissues while reducing glucose production by the liver. Additionally, insulin glargine inhibits processes like lipolysis and proteolysis, promoting protein synthesis within the body.

Dosage & Administration of

Insulin glargine is a long-acting insulin analog that maintains a consistent glucose-lowering effect over 24 hours, allowing for once-daily subcutaneous administration. The recommended initial dose may vary based on the type of diabetes and the patient's current insulin regimen. For patients with type 1 diabetes, it's advised to use insulin glargine in combination with short-acting insulin. The dose should be individualized and adjusted according to blood glucose levels. Blood glucose monitoring is crucial for all patients on insulin therapy.

Administer insulin glargine subcutaneously in the upper arm, thigh, or abdominal wall. Absorption is faster when injected into the abdominal wall. Do not administer it intravenously or through an insulin pump, as this could lead to severe hypoglycemia. Rotate injection sites to avoid lipodystrophy (skin changes) and use the same region for a series of injections.

The dosing for children and individuals with renal impairment may require adjustments. When injecting, cleanse the skin, use a 45° angle, inject, and then apply gentle pressure. Be cautious of factors like exercise, stress, illness, and coadministered drugs that can affect insulin absorption.

Insulin glargine should be taken at the same time every day for optimal results, even though it can be administered at any time. Always consult your doctor before making any changes to your insulin regimen or administration technique.

Interaction

Drug-Drug Interactions:

• Larsulin SC Injection 100IU/ml may interact with antidiabetic pills (sitagliptin), blood sugar enhancers (diazoxide), blood pressure-lowering pills (metoprolol, clonidine), antidepressants (lithium, fluoxetine), pain killers (aspirin, pentoxifylline, propoxyphene), anti-TB drug (isoniazid), growth hormone (somatropin), thyroid hormone-related drugs (levothyroxine), antipsychotic medicines (phenothiazine, clozapine, olanzapine), anti-cholesterol drugs (fenofibrate), anti-asthmatic drugs (epinephrine, salbutamol, terbutaline), and female hormones (oestrogens, progestogens).

Drug-Food Interactions:

• Larsulin SC Injection 100IU/ml may interact with ayurvedic, homoeopathy, Unani, herbal supplements, or over-the-counter (OTC) items. Inform your doctor if you use these products. Avoid alcohol consumption with Larsulin SC Injection 100IU/ml as it may affect your blood sugar level.

Drug-Disease Interactions:

• Larsulin SC Injection 100IU/ml should not be given to patients with kidney disease, liver disease, low blood sugar/glucose levels (hypoglycaemia), and low potassium levels (hypokalaemia).

Contraindications

Insulin glargine is contraindicated in patients with hypersensitivity to insulin glargine or any of its excipients.

Pregnancy & Lactation

• Pregnancy Category C. Insulin glargine should be used during pregnancy only if the potential benefit outweighs the possible risk to the fetus.
• Breastfeeding: It is not known whether insulin glargine is excreted in human milk. Since many drugs, including human insulin, are excreted in breast milk, care should be taken when administering insulin glargine to a nursing woman. Women who are breastfeeding may need dosage and diet adjustments of insulin.

Precautions & Warnings

• Larsulin SC Injection 100IU/ml is not suitable for treating diabetic ketoacidosis due to its delayed action. Consult your doctor for appropriate treatment options.
• Administer Larsulin SC Injection 100IU/ml only subcutaneously (under the skin), not intravenously or intramuscularly.
• Regularly monitor blood sugar levels, as Larsulin SC Injection 100IU/ml may lead to low blood sugar. Carry sugar candy to counteract low blood sugar effects.
• Do not mix or dilute Larsulin SC Injection 100IU/ml with other insulins or solutions to avoid altering effects or increasing side effects.
• Not recommended for children under 6 years due to lack of safety and efficacy data.
• Injection site reactions like redness, pain, itching, swelling, or hives may occur. Rotate injection sites to reduce these reactions.
• Blood glucose levels may affect your ability to drive or operate machines. Avoid doing so if you experience symptoms like dizziness or blurred vision.
• Be cautious of symptoms like sweating, anxiety, fast heartbeat, headache, and intense hunger, and seek help if they persist.
• Inform your doctor if you experience frequent fever and infections.
• Notify your doctor if you have these conditions.
• If changing insulin brands, consult your doctor for adjustments.
• Address pain, itching, and swelling by continuously changing the injection site.
• Be cautious about heavy exercise to prevent drastic blood glucose drops.
• If you plan to change your diet, consult your doctor.
• If taking insulin but not eating enough, blood glucose levels can drop significantly.

Storage Conditions

Store in a refrigerator (2 - 8°C). Do not freeze.